Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease that may involve many different organs and display a variable clinical course. The diagnosis of SLE is based on characteristic clinical findings of the skin, joints, kidneys and central nervous system, as well as on serological parameters such as antinuclear antibodies (ANA), in particular antibodies to DNA. The various clinical symptoms do not always occur simultaneously and may develop at any stage of the disease. In the early stages, physicians from various disciplines often propose several differential diagnosis, or identify only one aspect of the disease without recognizing the symptoms as part of SLE. Fever, fatigue and arthralgia are the most frequently occurring nonspecific symptoms at disease onset; additional joint swelling or a \"Discoid rash\" particularly in women of childbearing age should prompt consideration of SLE. Here we present a rare and unique case of Systemic Lupus Erythematosus seen in 21 years female patient.
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